Hygiena 2016, 61(3):119-123 | DOI: 10.21101/hygiena.a1436
Known or Still Unknown Drug Khat. Reasons for and Consequences of Chewing Khat Leaves
- 1 Masarykova univerzita, Lékařská fakulta, Ústav ochrany a podpory zdraví, Brno, Czech Republic
- 2 Thamar University, Faculty of Dentistry, Thamar, Yemen
In some African and Arabian peninsula countries, the chewing of khat leaves is a common habit. It contains many different chemicals, psychoactive alcaloids cathinon and cathin, among others. Khat (Catha edulis) has stimulative effects, its also produces a mild dependence and health damages among heavy users. At the end of the last century khat was included into the lists of to be narcotic drugs, both in WHO and in the Czech Republic. Conteporarly, khat is considered rather social and economic risk, both for individual users and for countries growing khat. In other continents, the problems of khat chewing concern predominantly immigrants from Africa. The publication offers brief information on this topic.
Keywords: drug addiction, khat, mental health, morbidity
Received: November 2015; Accepted: January 15, 2016; Published: September 1, 2016 Show citation
References
- Khat: fast facts: questions and answers. Washington: U.S. Department of Justice, National Drug Intelligence Center; 2008.
- Al-Motarreb A, Baker K, Broadley KJ. Khat: pharmacological and medical aspects and its social use in Yemen. Phytother Res. 2002 Aug;16(5):403-13.
Go to original source...
Go to PubMed...
- Cox G, Rampes H. Adverse effects of khat: a review. Adv Psychiatr Treat. 2003;9(6):456-63.
Go to original source...
- Nencini P, Ahmed AM. Khat consumption: a pharmacological review. Drug Alcohol Depend. 1989 Jan;23(1):19-29.
Go to original source...
Go to PubMed...
- Geisshüsler S, Brenneisen R. The content of psychoactive phenylpropyl and phenylpentenyl khatamines in Catha edulis Forsk. of different origin. J Ethnopharmacol. 1987 May;19(3):269-77.
Go to original source...
Go to PubMed...
- Medeshi news. Khat and its effects on the health of consumers [Internet]. Medeshi Media Group; 2015 [cited 2016 Jan 15]. Available from: http://www.medeshivalley.com/2015/07/khat-and-its-effects-on-health-of.html.
- Muharam I. Alternatives for replacing the cultivation of khat. San'á: The Ebadi Centre for Studies and Publications; 2002. (In Arabic.)
- Numan N. The green leaf: khat. World J Med Sci. 2012;7(4):210-23.
- Manghi RA, Broers B, Khan R, Benguettat D, Khazaal Y, Zullino DF. Khat use: lifestyle or addiction? J Psychoactive Drugs. 2009 Mar;41(1):1-10.
Go to original source...
Go to PubMed...
- Khawaja M, Al-Nsour M, Saad G. Khat (Catha edulis) chewing during pregnancy in Yemen: findings from a national population survey. Matern Child Health J. 2008 May;12(3):308-12.
Go to original source...
Go to PubMed...
- Numan N. Exploration of adverse psychological symptoms in Yemeni khat users by the Symptoms Checklist-90 (SCL-90). Addiction. 2004 Jan;99(1):61-5.
Go to original source...
Go to PubMed...
- Zeleke A, Awoke W, Gebeyehu E, Ambaw F. Khat chewing practice and its percieved health effects among communities of Dera Woreda, Amhara region, Ethiopia. Open J Epidemiol. 2013;3(4):160-8.
Go to original source...
- Omar A, Besseling R. Khat - a drug of growing abuse. Bloms Tryckeri AB; 2008.
- Al-Abed AA, Sutan R, Al-Dubai SA, Aljunid SM. Family context and Khat chewing among adult Yemeni women: a cross-sectional study. Biomed Res Int. 2014;2014:505474.
Go to original source...
Go to PubMed...
- Alem A, Kebede D, Kullgren G. The prevalence and socio-demographic correlates of khat chewing in Butajira, Ethiopia. Acta Psychiatr Scand Suppl. 1999;397:84-91.
Go to original source...
Go to PubMed...
- Halket JM, Karasu Z, Murray-Lyon IM. Plasma cathinone levels following chewing khat leaves (Catha edulis Forsk.). J Ethnopharmacol. 1995 Dec 1;49(2):111-3.
Go to original source...
Go to PubMed...
- Toennes SW, Harder S, Schramm M, Niess C, Kauert GF. Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003 Jul;56(1):125-30.
Go to original source...
- Nencini P, Ahmed AM. Khat consumption: a pharmacological review. Drug Alcohol Depend. 1989 Jan;23(1):19-29.
Go to original source...
Go to PubMed...
- Pantelis C, Hindler CG, Taylor JC. Khat, toxic reactions to this substance, its similarities to amphetamine, and the implications of treatment for such patients. J Subst Abuse Treat. 1989;6(3):205-6.
Go to original source...
- Hassan NA, Gunaid AA, El Khally FM, Murray-Lyon IM. The subjective effects of chewing Qat leaves in human volunteers. Ann Saudi Med. 2002 Jan-Mar;22(1-2):34-7.
Go to original source...
Go to PubMed...
- Kalix P. Pharmacological properties of the stimulant khat. Pharmacol Ther. 1990;48(3):397-416.
Go to original source...
- Jager AD, Sireling L. Natural history of Khat psychosis. Aust N Z J Psychiatry. 1994 Jun;28(2):331-2.
Go to original source...
Go to PubMed...
- Odenwald M. Chronic khat use and psychotic disorders: a review of the literature and future prospects. Sucht. 2007;53(1):9-22.
Go to original source...
- Bhui K, Abdi A, Abdi M, Pereira S, Dualeh M, Robertson Det al. Traumatic events, migration characteristics and psychiatric symptoms among Somali refugees - preliminary communication. Soc Psychiatry Psychiatr Epidemiol. 2003 Jan;38(1):35-43.
Go to original source...
Go to PubMed...
- Granek M, Shalev A, Weingarten AM. Khat-induced hypnagogic hallucinations. Acta Psychiatr Scand. 1988 Oct;78(4):458-61.
Go to original source...
Go to PubMed...
- Toennes SW, Kauert GF. Driving under the influence of khat - alkaloid concentrations and observations in forensic cases. Forensic Sci Int. 2004 Feb 10;140(1):85-90.
Go to original source...
Go to PubMed...
- Pennings EJ, Opperhuizen A, van Amsterdam JG. Risk assessment of khat use in the Netherlands: a review based on adverse health effects, prevalence, criminal involvement and public order. Regul Toxicol Pharmacol. 2008 Dec;52(3):199-207.
Go to original source...
Go to PubMed...
- Belew M, Kebede D, Kassaye M, Enquoselassie F. The magnitude of khat use and its association with health, nutrition and socio-economic status. Ethiop Med J. 2000 Jan;38(1):11-26.
Go to PubMed...
- Al-Motarreb A, Briancon S, Al-Jaber N, Al-Adhi B, Al-Jailani F, Salek MS, et al. Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br J Clin Pharmacol. 2005 May;59(5):574-81.
Go to original source...
Go to PubMed...
- Dhaifalah I, Santavý J. Khat habit and its health effect. A natural amphetamine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004 Jul;148(1):11-5.
Go to original source...
Go to PubMed...
- Birhane WB, Birhane MW. The effect of Khat (Catha edulis) chewing on blood pressure among male adult chewers, Bahir Dar, North West Ethiopia. Sci J Publ Health. 2014;2(5): 461-68.
Go to original source...
- Sheikh KA, El-Setouhy M, Yagoub U, Alsanosy R, Ahmed Z. Khat chewing and health related quality of life: cross-sectional study in Jazan region, Kingdom of Saudi Arabia. Health Qual Life Outcomes. 2014 Apr 4;12:44. doi: 10.1186/1477-7525-12-44.
Go to original source...
Go to PubMed...
- Al-Hadrani AM. Khat induced hemorrhoidal disease in Yemen. Saudi Med J. 2000 May;21(5):475-7.
Go to PubMed...
- Hakim LY. Influence of khat on seminal fluid among presumed infertile couples. East Afr Med J. 2002 Jan;79(1):22-8.
Go to original source...
- Nabuzoka D, Badhadhe FA. Use and perception of khat among young Somalis in a UK city. Addict Res. 2000;8:5-26.
Go to original source...
- Mwenda JM, Arimi MM, Kyama MC, Langat DK. Effects of khat (Catha edulis) consumption on reproductive functions: a review. East Afr Med J. 2003 Jun;80(6):318-23.
Go to original source...
- Kassie F, Darroudi F, Kundi M, Schulte-Hermann R, Knasmüller S. Khat (Catha edulis) consumption causes genotoxic effects in humans. Int J Cancer. 2001 May 1;92(3):329-32.
Go to original source...
Go to PubMed...
- Mengel R, Eigenbrodt M, Schünemann T, Florès-de-Jacoby L. Periodontal status of a subject sample of Yemen. J Clin Periodontol. 1996 May;23(5):437-43.
Go to original source...
Go to PubMed...
- Al-Hebshi NN, Skaug N. Effect of khat chewing on 14 selected periodontal bacteria in sub- and supragingival plaque of a young male population. Oral Microbiol Immunol. 2005 Jun;20(3):141-6.
Go to original source...
Go to PubMed...
- Gorsky M, Epstein JB, Levi H, Yarom N. Oral white lesions associated with chewing khat. Tob Induc Dis. 2004 Sep 15;2(3):145-50.
Go to original source...
Go to PubMed...
- Soufi HE, Kameswaran M, Malatani T. Khat and oral cancer. J Laryngol Otol. 1991 Aug;105(8):643-5.
Go to original source...
Go to PubMed...
- Al-Sharafi BA, Gunaid AA. Effect of habitual Khat chewing on glycemic control, body mass index, and age at diagnosis of diabetes in patients with type 2 diabetes mellitus in Yemen. Clin Med Insights Endocrinol Diabetes. 2015 Jun 2;8:47-53.
Go to original source...
Go to PubMed...
- Abebe D, Debella A, Dejene A, Degefa A, Abebe A, Urga, et al. Khat chewing habit as a possible risk behaviour for HIV infection. A case-control study. Ethiop J Health Dev. 2005; 19(3):174-81.
Go to original source...
- Nařízení vlády č. 467/2009, ze dne 14. prosince 2009, kterým se pro účely trestního zákoníku stanoví, co se považuje za jedy a jaké je množství větší než malé u omamných látek, psychotropních látek, přípravků je obsahujících a jedů. Sbírka zákonů ČR. 2009;částka 148:7550-70.
- Nařízení vlády č. 463/2013, ze dne 18. prosince 2013, o seznamech návykových látek. Sbírka zákonů ČR. 2013;178:7774-88.
- DrugFacts. Khat [Internet]. Bethesda: National Institute on Drug Abuse; 2013 [cited 2013 April 10]. Available from: https://www.drugabuse.gov/sites/default/files/drugfacts_khat_final.pdf.
- Stefan J, Mathew B. Khat chewing: an emerging drug concern in Australia? Aust N Z J Psychiatry. 2005 Sep;39(9):842-3.
Go to original source...
Go to PubMed...
- Patel SL, Wright S, Gammampila A. Khat use among Somalis in four English cities. Home Office online report 47/05 [Internet]. Home Office, Research Development and Statistics Directorate; 2005 [cited 2016 Jan 15]. Availble from: http://karin-ha.org.uk/wp-content/uploads/2013/01/rdsolr4705.pdf.
- Lakew A, Tariku B, Deyessa N, Reta Y. Prevalence of Catha edulis (Khat) chewing and its associated factors among Ataye Secondary School Students in Northern Shoa, Ethiopia. Adv Appl Sociol. 2014;4(10):225-33.
Go to original source...
- Dessie G. Is khat a social ill? Ethical arguments about a 'stimulant' among the learned Ethiopians. ASC Working Paper 108/2013. Leiden: African Studies Centre; 2013.
- Elmi AS. The chewing of khat in Somalia. J Ethnopharmacol. 1983 Aug;8(2):163-76.
Go to original source...
Go to PubMed...
- Kennedy JG, Teague J, Fairbanks L. Qat use in North Yemen and the problem of addiction: a study in medical anthropology. Cult Med Psychiatry. 1980 Dec;4(4):311-44.
Go to original source...
Go to PubMed...
- Odenwald M, Neuner F, Schauer M, Elbert T, Catani C, Lingenfelder B, et al. Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in Somalia. BMC Med. 2005 Feb 12;3:5. doi.10.1186/1741-7015-3-5.
Go to original source...
Go to PubMed...