Hygiena 2013, 58(4):167-170 | DOI: 10.21101/hygiena.a0984

Epigenetic Effects of Cigarette Smoke in Carcinogenesis

Drahoslava Hrubá
Masarykova univerzita, Lékařská fakulta, Ústav preventivního lékařství, Brno

Cigarette smoke contains unique amounts of human carcinogens, including tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons. These two families of genotoxic chemicals and nicotine also play an important role in stages of tumorigenesis promotion and progression through epigenetic (non-genotoxic) mechanisms. Probably the most important pathways are activation of certain nicotinic acetylcholine receptors (nAChR), β adrenoreceptors (β AR) and aryl hydrocarbone receptors (AhR) by these chemicals. The activation of these receptors results in the release of growth factors and neurotransmitters which influence cell proliferation and protein synthesis, inhibition of apoptosis, mitochondrial dysfunction, angiogenesis, tumor invasion and metastasis.

Keywords: carcinogenesis, epigenetics, cigarette smoke

Received: August 2012; Accepted: August 27, 2012; Published: December 1, 2013  Show citation

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Hrubá D. Epigenetic Effects of Cigarette Smoke in Carcinogenesis. Hygiena. 2013;58(4):167-170. doi: 10.21101/hygiena.a0984.
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