Hygiena 2010, 55(2):58-60

Women Have Greater Difficulties in Stopping Smoking: Are Sex Hormones Implicated?

Drahoslava Hrubá1, Jindřich Fiala1, Kateřina Nebeská1, Vladimír Soška2
1 Lékařská fakulta Masarykovy univerzity, Ústav preventivního lékařství, Brno
2 Lékařská fakulta Masarykovy univerzity, Fakultní nemocnice U sv. Anny, Klinický komplement, Brno

Gender differences in the successful treatment of smoking dependence have been identified; women have greater difficulties in quitting smoking compared to men. Women reported higher levels of withdrawal symptoms and craving and diminished effectiveness of nicotine replacement therapy. Sex hormones, especially estrogen, may play a role both in the metabolism of nicotine, cortisol concentrations, carving, withdrawal symptoms and risk of relapse.

Keywords: smoking cessation, menstrual cycle, hormonal contraceptives

Received: June 2009; Accepted: December 11, 2009; Published: June 1, 2010  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hrubá D, Fiala J, Nebeská K, Soška V. Women Have Greater Difficulties in Stopping Smoking: Are Sex Hormones Implicated? Hygiena. 2010;55(2):58-60.
Download citation

References

  1. Al'Absi M. Hypothalamic-pituitary-adrenocortical responses to psychological stress and risk for smoking relapse. Int J Psychophysiol. 2006 Mar;59(3):218-27. Go to original source... Go to PubMed...
  2. Allen SS, Bade T, Center B, Finstad D, Hatsukami D. Menstrual phase effects on smoking relapse. Addiction. 2008 May;103(5):809-21. Go to original source... Go to PubMed...
  3. Allen AM, Allen SS, Widenmier J, Al'Absi M. Patterns of cortisol and craving by menstrual phase in women attempting to quit smoking. Addict Behav. 2009 Aug;34(8):632-5. Go to original source... Go to PubMed...
  4. Andreano JM, Arjomandi H, Cahill L. Menstrual cycle modulation of the relationship between cortisol and long-term memory. Psychoneuroendocrinology. 2008 Jul;33(6):874-82. Go to original source... Go to PubMed...
  5. Back SE, Waldrop AE, Saladin ME, Yeatts SD, Simpson A, McRae AL, et al. Effects of gender and cigarette smoking on reactivity of psychological and pharmacological stress provocation. Psychoneuroendocrinology. 2008 Jun;33(5):560-8. Go to original source... Go to PubMed...
  6. Benowitz NL, Lessov-Schlaggar CN, Swan GE, Jacob P 3rd. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther. 2006 May;79(5):480-8. Go to original source... Go to PubMed...
  7. Bjornson W, Rand C, Connett JE, Lindgren P, Nides M, Pope F, et al. Gender differences in smoking cessation after 3 years in the Lung Health Study. Am J Public Health. 1995 Feb;85(2):223-30. Go to original source...
  8. Carpenter MJ, Saladin ME, Leinbach AS, Larowe SD, Upadhyaya HP. Menstrual cycle phase effects on smoking cessation: a pilot feasibility study. J Womens Health (Larchmt). 2008 Mar;17(2):293-301. Go to original source... Go to PubMed...
  9. Dickmann PJ, Mooney ME, Allen SS, Hanson K, Hatsukami DK. Nicotine withdrawal and craving in adolescents: effects of sex and hormonal contraceptive use. Addict Behav. 2009 Jun-Jul;34(6-7):620-3. Go to original source... Go to PubMed...
  10. Disshon KA, Dluzen DE. Use in vitro superfusion to assess the dynamics of striatal dopamine clearance: influence of estrogen. Brain Res. 1999 Sep 25;842(2):399-407. Go to original source...
  11. Franklin TR, Ehrman R, Lynch KG, Harper D, Sciortino N, O'Brien CP, et al. Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis. J Womens Health (Larchmt). 2008 Mar;17(2):287-92. Go to original source... Go to PubMed...
  12. Hogle JM, Curtin JJ. Sex differences in negative affective response during nicotine withdrawal. Psychophysiology. 2006 Jul;43(4):344-56. Go to original source... Go to PubMed...
  13. Kirshbaum C, Kudielka BM, Gaab J, Schommer NC, Hell-hammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med. 1999 Mar-Apr;61(2):154-62. Go to original source... Go to PubMed...
  14. Leventhal AM, Waters AJ, Boyd S, Moolchan ET, Lerman C, Pickworth WB. Gender differences in acute tobacco withdrawal: effects on subjective, cognitive and physiological measures. Exp Clin Psychopharmacol. 2007 Feb;15(1):21-36. Go to original source... Go to PubMed...
  15. Marks JL, Pomerleau CS, Pomerleau OF. Effects of menstrual phase on reactivity to nicotine. Addict Behav. 1999 Jan-Feb;24(1):127-34. Go to original source... Go to PubMed...
  16. Panday S, Reddy SP, Ruiter RA, Bergström E, de Vries H. Nicotine dependence and withdrawal symptoms among occasional smokers. J Adolesc Health. 2007 Feb;40(2):144-50. Go to original source... Go to PubMed...
  17. Perkins KA. Smoking cessation in women. Special considerations. CNS Drugs. 2001;15(5):391-411. Go to original source... Go to PubMed...
  18. Rasmusson AM, Wu R, Paliwal P, Anderson GM, KrishnanSarin S. A decrease in the plasma DHEA to cortisol ratio during smoking abstinence may predict relapse: a preliminary study. Psychopharmacology (Berl). 2006 Jun;186(3):473-80. Go to original source... Go to PubMed...
  19. Smith AE, Cavallo DA, Dahl T, Wu R, George TP, Krishnan-Sarin S. Effects of accute tobacco abstinence in adolescent smokers compared with nonsmokers. J Adolesc Health. 2008 Jul;43(1):46-54. Go to original source... Go to PubMed...
  20. Swan GE, Jack LM, Ward MM. Subgroups of smokers with difference success rates after use transdermal nicotine. Addiction. 1997 Feb;92(2):207-17. Go to original source... Go to PubMed...
  21. Thompson TL, Moss RL. Estrogen regulation of dopamine release in the nucleus accumbens: genomic- and nongenomic-mediated effects. J Neurochem. 1994 May;62(5):1750-6. Go to original source... Go to PubMed...
  22. Ussher M, West R, Evans P, Steptoe A, McEwen A, Clow A, et al. Reduction in cortisol after smoking cessation among users of nicotine patches. Psychosom Med. 2006 MarApr;68(2):299-306. Go to original source... Go to PubMed...
  23. Wolf OT, Schommer NC, Hellhammer DH, McEwen BS, Kirschbaum C. The relationship between stress induced cortisol levels and memory differs between men and women. Psychoneuroendocrinology. 2001 Oct;26(7):711-20. Go to original source... Go to PubMed...