Hygiena 2009, 54(2):40-43

Exposure to Polyhalogenated Hydrocarbons and Incidence of Selected Malignancies

Vladimír Bencko1, Jiří Rameš1, Lenka Juříčková2
1 Univerzita Karlova v Praze, 1. LF UK & VFN, Ústav hygieny a epidemiologie
2 Ústav zdravotnických informací a statistiky ČR, Praha

Increased polyhalogenated hydrocarbons were found in breast milk fat samples collected in the Uherské Hradiště (UH) District compared to that of five other sampled regions throughout the Czech Republic. The content of lipophilic xenobiotics corresponded to the values detected in breast milk samples in Eastern Slovakia, Michalovce District, that were collected according to the same protocol within the 5th FP PCBRisk QLK 4-2000-00488. The Michalovce District revealed lower than expected incidence of breast and prostate malignancies. According to the same protocol, the authors performed an analysis of the same spectrum of malignancies in the UH district in comparison with the incidence of malignancies in the Czech Republic in the course of the same time period of ten years (1987-1996). Throughout this ten year period collected dataset for the Czech Republic represents ∼103 M and for the UH District ∼1.46 M person years. Statistical significance in the difference was evaluated using the two sample paired t-test of the means in STATISTICA 6.0 software. The age adjusted world standard ratio (WSR) incidence was not higher in the UH district but significantly lower (p<0.01). The risk for bladder cancer for the both sexes was observed lower than expected in comparison with relevant data for the Czech Republic. To sum up, the results of our analysis points to substantial potential problems of risk assessment for cancer incidence in populations exposed to xenobiotics, or more generally, as it relates to a wide spectrum of confoundings of cancer risk factors. Lastly, anti-estrogenic and anti-androgenic properties described for hydroxylated and methylsulfonyl PCB metabolites might substantially modulate the carcinogenic potential of PCBs.

Keywords: polyhalogenated hydrocarbons, cancer epidemiology, bladder cancer, cancer registry

Received: December 2008; Accepted: March 3, 2009; Published: June 1, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bencko V, Rameš J, Juříčková L. Exposure to Polyhalogenated Hydrocarbons and Incidence of Selected Malignancies. Hygiena. 2009;54(2):40-43.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Aronson KJ, Miller AB, Woolcott CG, Sterns EE, McCready DR, Lickley LA, et al. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):55-63. Go to PubMed...
    2. Bencko V, Skulová Z, Krečmerová M, Liem AK. Selected polyhalogenated hydrocarbons in breast milk. Toxicol Lett. 1998 Aug;96-97:341-5. Go to original source... Go to PubMed...
    3. Bencko V. Risk assessment and human exposure to endocrine disrupters. In: Jedrychowski WA, Perera FP, Maugeri U, editors. Molecular epidemiology in preventive medicine. Luxembourg: International Center for Studies and Research in Biomedicine; 2003. p. 315-27.
    4. Bencko V. Nádorová onemocnění. In: Zvárová J, Malý M, editoři. Statistické metody v epidemiologii. Svazek 2. Praha: Nakladatelství Karolinum; 2003. s. 413-37.
    5. Bencko V, Černá M, Jech L, Šmíd J. Exposure of breast0,9 0,8 1,1 0,0 1,2 2,3 2,0 2,7 1,9 1,8 3,0 2,8 3,1 3,1 3,7 3,6 4,1 4,3 4,6 5,1 R<sup>2</sup> = 0,4887 R<sup>2</sup> = 0,9325 0,0 1,0 2,0 3,0 4,0 5,0 6,0 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 WSR roky ŽENY Uherské Hradiště Česká republika Obr. 2: Lineární regrese WSR hodnot incidence karcinomu moèového měchýøe žen v ÈR a v okrese Uherské Hradiště. 10,8 13,0 6,1 4,9 7,5 10,7 15,2 14,0 9,3 16,3 14,3 14,4 13,6 15,5 16,4 17,8 17,9 18,0 18,9 19,9 R<sup>2</sup> = 0,2125 R<sup>2</sup> = 0,9219 0,0 5,0 10,0 15,0 20,0 25,0 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 WSR roky MUŽI Uherské Hradiště Česká republikafed children in the Czech Republic to PCDDs, PCDFs, and dioxin-like PCBs. Environ Toxicol Pharmacol. 2004 Nov;18(2):83-90. Go to original source... Go to PubMed...
    6. Bencko V, Rameš J, van den Berg M, Pleško I, Trnovec T. Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies. In: Donnelly KC, Cizmas LH, editors. Environmental health in Central and Eastern Europe. Dordrechrt: Springer; 2006. p. 31-7. Go to original source...
    7. Černá M, Bencko V. Polyhalogenated hydrocarbons: body burden of the Czech and Slovak populations. I. Polychlorinated biphenyls. Cent Eur J Public Health. 1999;7(2):67-71.
    8. De Rosa CT, Pohl HR, Bencko V, Richter P, Jones DE. Zdravotní rizika xenobiotik ovlivňujících endokrinní systém. I. Ekologické aspekty a mechanismus jejich působení. Prakt Lék. 2001;81(9):490-4.
    9. De Rosa CT, Pohl HR, Bencko V, Richter P, Jones DE. Zdravotní rizika xenobiotik ovlivňujících endokrinní systém. II. Důsledky pro zdraví člověka a strategie prevence., Prakt Lék. 2001;81(11):619-23.
    10. Güttes S, Failing K, Neumann K, Kleinstein J, Georgii S, Brunn H. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol. 1998 Jul;35(1):140-7. Go to original source... Go to PubMed...
    11. Helzlsouer KJ, Alberg AJ, Huang HY, Hoffman SC, Strickland PT, Brock JW, et al. Serum concentrations of organochlorine compounds and the subsequent development of breast cancer. Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):525-32. Go to PubMed...
    12. 12/ Kočan A, Petrik J, Jursa S, Chovancová J, Drobná B. Environmental contamination with polychlorinated biphenyls in the area of their former manufacture in Slovakia. Chemosphere. 2001 May-Jun;43(4-7):595-600. Go to PubMed...
    13. Laden F, Ishibe N, Hankinson SE, Wolff MS, Gertig DM, Hunter DJ, et al. Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study. Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1560-5. Go to PubMed...
    14. Lucena RA, Allam MF, Costabeber IH, Villarejo ML, Navajas RF. Breast cancer risk factors: PCB congeners. Eur J Cancer Prev. 2001 Feb;10(1):117-9. Go to original source...
    15. Pavuk M, Cerhan JR, Lynch CF, Schecter A, Petrik J, Chovancova J, et al. Environmental exposure to PCBs and cancer incidence in eastern Slovakia. Chemosphere. 2004 Mar;54(10):1509-20. Go to original source... Go to PubMed...
    16. Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol. 1994;24(2):87-149. Go to original source... Go to PubMed...
    17. Sasco AJ. Cancer and globalization. Biomed Pharmacother. 2008 Feb;62(2):110-21. Go to original source... Go to PubMed...
    18. Trnovec T, Bencko V, Langer P, van den Berg M, Kocan A, Bergman A, et al. Study design, objectives, hypotheses, main findings, health consequences for the population exposed, rationale of future research. PCBRISK Project Slovakia. Organohalogen Compd. 2004;66:3573-9.
    19. WHO European Centre for Environment and Health. Levels of PCBs, PCDDs and PCDFs in human milk: second round of WHO-coordinated exposure study. Environmental health in Europe. Series 3:121. Bilthoven: Health Organization European Centre for Environment and Health; 1996.
    20. Wolff MS, Zeleniuch-Jacquotte A, Dubin N, Toniolo P. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271-7. Go to PubMed...
    21. Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, et al. Breast cancer risk associated with congeners of polychlorinated biphenyls. Am J Epidemiol. 2000 Jul 1;152(1):50-8. Poděkování Tato studie navazuje na projekt 5RP "Hodnocení zdravotních rizik nízké dlouhodobé expozice polychlorovaným bifenylům (PCBRisk QLK4-2000-00488)". Byla umožněna díky pochopení vedení Národního onkologického registru ČR v rámci aktivit projektu CASCADE Network of Excellence NoE FOOD-CT-2004-506319. Go to original source... Go to PubMed...

    Return to the content